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Index > Protein center > NR4A2(Gene name) > Human
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  • NR4A2 (Gene name),
  • Nuclear receptor subfamily 4 group A member 2 (Protein name ),  NR4A2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NR4A2(NOT;NURR1;TINUR);
    Protein name:
    Nuclear receptor subfamily 4 group A member 2;
    Alternative:
    Orphan nuclear receptor NURR1;Immediate-early response protein NOT;Transcriptionally-inducible nuclear receptor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3.
    Function:
    Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    598
    Sequence:
    50:
    MPCVQAQYGS | SPQGASPASQ | SYSYHSSGEY | SSDFLTPEFV | KFSMDLTNTE | 
    100:
    ITATTSLPSF | STFMDNYSTG | YDVKPPCLYQ | MPLSGQQSSI | KVEDIQMHNY | 
    150:
    QQHSHLPPQS | EEMMPHSGSV | YYKPSSPPTP | TTPGFQVQHS | PMWDDPGSLH | 
    200:
    NFHQNYVATT | HMIEQRKTPV | SRLSLFSFKQ | SPPGTPVSSC | QMRFDGPLHV | 
    250:
    PMNPEPAGSH | HVVDGQTFAV | PNPIRKPASM | GFPGLQIGHA | SQLLDTQVPS | 
    300:
    PPSRGSPSNE | GLCAVCGDNA | ACQHYGVRTC | EGCKGFFKRT | VQKNAKYVCL | 
    350:
    ANKNCPVDKR | RRNRCQYCRF | QKCLAVGMVK | EVVRTDSLKG | RRGRLPSKPK | 
    400:
    SPQEPSPPSP | PVSLISALVR | AHVDSNPAMT | SLDYSRFQAN | PDYQMSGDDT | 
    450:
    QHIQQFYDLL | TGSMEIIRGW | AEKIPGFADL | PKADQDLLFE | SAFLELFVLR | 
    500:
    LAYRSNPVEG | KLIFCNGVVL | HRLQCVRGFG | EWIDSIVEFS | SNLQNMNIDI | 
    550:
    SAFSCIAALA | MVTERHGLKE | PKRVEELQNK | IVNCLKDHVT | FNNGGLNRPN | 
    598:
    YLSKLLGKLP | ELRTLCTQGL | QRIFYLKLED | LVPPPAIIDK | LFLDTLPF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nuclear receptor subfamily 4 group A member 2
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    ELISA Kit for Human Nuclear receptor subfamily 4 group A member 2
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    ELISA Kit for Human Nuclear receptor subfamily 4 group A member 2
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    ELISA Kit for Human Nuclear receptor subfamily 4 group A member 2
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    E15148b
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    CLIA Kit for Human Nuclear receptor subfamily 4 group A member 2
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    U15148r
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    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 4 group A member 2
    Cat.:
    U15148b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 4 group A member 2
    Cat.:
    U15148m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Nuclear receptor subfamily 4 group A member 2
    Cat.:
    U15148h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Cat.:
    P15148Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Polyclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Cat.:
    P15148Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Cat.:
    P15148Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Monoclonal Antibody for Human Nuclear receptor subfamily 4 group A member 2
    Protein for Human Nuclear receptor subfamily 4 group A member 2
    Protein for Human Nuclear receptor subfamily 4 group A member 2
    Protein for Human Nuclear receptor subfamily 4 group A member 2
    Protein for Human Nuclear receptor subfamily 4 group A member 2

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    References
    1. 1.
      "NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3."
      Mages H.W. , Rilke O. , Bravo R. , Senger G. , Kroczek R.A.
      Mol. Endocrinol.8:1583-1591(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Blood.
    2. 2.
      "Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs."
      Ichinose H. , Ohye T. , Suzuki T. , Sumi-Ichinose C. , Nomura T. , Hagino Y. , Nagatsu T.
      Gene230:233-239(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Fibroblast.
    3. 3.
      "Organization of the human orphan nuclear receptor Nurr1 gene."
      Torii T. , Kawarai T. , Nakamura S. , Kawakami H.
      Gene230:225-232(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Skin.
      tissue: Testis.
    8. 8.
      "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line."
      Okabe T. , Takayanagi R. , Imasaki K. , Haji M. , Nawata H. , Watanabe T.
      J. Immunol.154:3871-3879(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 59-598 (ISOFORM 1)
    9. 9.
      "Induction of tyrosine hydroxylase expression by the transcription factor Pitx3."
      Messmer K. , Remington M.P. , Skidmore F. , Fishman P.S.
      Int. J. Dev. Neurosci.25:29-37(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress."
      Garcia-Yague A.J. , Rada P. , Rojo A.I. , Lastres-Becker I. , Cuadrado A.
      J. Biol. Chem.288:5506-5517(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR LOCALIZATION SIGNALS;NUCLEAR EXPORT SEQUENCES
    12. 12.
      "Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors."
      Wang Z. , Benoit G. , Liu J. , Prasad S. , Aarnisalo P. , Liu X. , Xu H. , Walker N.P. , Perlmann T.
      Nature423:555-560(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 328-598
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